Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress

The “last resort” pathway results in ubiquitylation and degradation of RNA polymerase II in response to transcription stress and is governed by factors such as Def1 in yeast. Here, we show that the SMY2 gene acts as a multi-copy suppressor of DEF1 deletion and functions at multiple steps of the last...

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Detalles Bibliográficos
Autores principales: Lehner, Michelle Harreman, Walker, Jane, Temcinaite, Kotryna, Herlihy, Anna, Taschner, Michael, Berger, Adam C., Corbett, Anita H., Dirac Svejstrup, A. Barbara, Svejstrup, Jesper Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638028/
https://www.ncbi.nlm.nih.gov/pubmed/36288698
http://dx.doi.org/10.1016/j.celrep.2022.111536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638028/
https://www.ncbi.nlm.nih.gov/pubmed/36288698
http://dx.doi.org/10.1016/j.celrep.2022.111536

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