Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening

Poly (ADP-ribose) polymerase 1 (PARP-1) is a critical enzyme involved in DNA damage repair and recombination, and shows great potential for drug development in the treatment of cancers with defective DNA repair. The anti-tumor activities of PARP-1 inhibitors are regulated by both inhibition activiti...

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Detalles Bibliográficos
Autores principales: Shi, Danfeng, Pang, Qianqian, Qin, Qianyu, Yao, Xinsheng, Yao, Xiaojun, Yu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638114/
https://www.ncbi.nlm.nih.gov/pubmed/36353483
http://dx.doi.org/10.3389/fphar.2022.1026306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638114/
https://www.ncbi.nlm.nih.gov/pubmed/36353483
http://dx.doi.org/10.3389/fphar.2022.1026306

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