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KCl-induced repetitive cortical spreading depression inhibiting trigeminal neuronal firing is mediated by 5-HT(1B/1D) and opioid receptors

BACKGROUND: We aimed to examine the effects of repetitive cortical spreading depression on the responses of nociceptive trigeminal neurons with dural afferents and characterize the role of 5-HT(1B/1D) and opioid receptors. METHODS: Trigeminocervical complex neurons (n = 53) responsive to nociceptive...

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Detalles Bibliográficos
Autores principales: Supronsinchai, Weera, Hoffmann, Jan, Akerman, Simon, Goadsby, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638706/
https://www.ncbi.nlm.nih.gov/pubmed/35833238
http://dx.doi.org/10.1177/03331024221112998