A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformation

Enhancer of Zeste Homolog 2 (EZH2) and androgen receptor (AR) are crucial chromatin/gene regulators involved in the development and/or progression of prostate cancer, including advanced castration-resistant prostate cancer (CRPC). To sustain prostate tumorigenicity, EZH2 establishes non-canonical bi...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Park, Kwang-Su, Yu, Xufen, Gong, Weida, Earp, H Shelton, Wang, Gang Greg, Jin, Jian, Cai, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638897/
https://www.ncbi.nlm.nih.gov/pubmed/36300627
http://dx.doi.org/10.1093/nar/gkac861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638897/
https://www.ncbi.nlm.nih.gov/pubmed/36300627
http://dx.doi.org/10.1093/nar/gkac861

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