A functional SNP regulates E-cadherin expression by dynamically remodeling the 3D structure of a promoter-associated non-coding RNA transcript

Transcription of E-cadherin, a tumor suppressor that plays critical roles in cell adhesion and the epithelial-mesenchymal transition, is regulated by a promoter-associated non-coding RNA (paRNA). The sense-oriented paRNA (S-paRNA) includes a functional C/A single nucleotide polymorphism (SNP rs16260...

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Detalles Bibliográficos
Autores principales: Sharma, Shrikant, Pisignano, Giuseppina, Merulla, Jessica, Catapano, Carlo V, Varani, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638923/
https://www.ncbi.nlm.nih.gov/pubmed/36243981
http://dx.doi.org/10.1093/nar/gkac875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638923/
https://www.ncbi.nlm.nih.gov/pubmed/36243981
http://dx.doi.org/10.1093/nar/gkac875

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