USP15 promotes cGAS activation through deubiquitylation and liquid condensation

Double-stranded DNA (dsDNA) is recognized as a danger signal by cyclic GMP-AMP synthase (cGAS), which triggers innate immune responses. cGAS activity must be properly regulated to maintain immune homeostasis. However, the mechanism by which cGAS activation is controlled remains to be better understo...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Chengrui, Yang, Xikang, Hou, Yanfei, Jin, Xue, Guo, Lerui, Zhou, Yi, Zhang, Conggang, Yin, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638925/
https://www.ncbi.nlm.nih.gov/pubmed/36243958
http://dx.doi.org/10.1093/nar/gkac823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638925/
https://www.ncbi.nlm.nih.gov/pubmed/36243958
http://dx.doi.org/10.1093/nar/gkac823

Ejemplares similares