CRISPR/Cas9-induced structural variations expand in T lymphocytes in vivo

CRISPR/Cas9 has been adapted to disrupt endogenous genes in adoptive T-lymphocyte therapy to prevent graft-versus-host disease. However, genome editing also generates prevalent deleterious structural variations (SVs), including chromosomal translocations and large deletions, raising safety concerns...

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Detalles Bibliográficos
Autores principales: Wu, Jinchun, Zou, Ziye, Liu, Yang, Liu, Xuhao, Zhangding, Zhengrong, Xu, Mo, Hu, Jiazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638931/
https://www.ncbi.nlm.nih.gov/pubmed/36243978
http://dx.doi.org/10.1093/nar/gkac887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638931/
https://www.ncbi.nlm.nih.gov/pubmed/36243978
http://dx.doi.org/10.1093/nar/gkac887

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