ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site

ADARs (adenosine deaminases acting on RNA) can be directed to sites in the transcriptome by complementary guide strands allowing for the correction of disease-causing mutations at the RNA level. However, ADARs show bias against editing adenosines with a guanosine 5′ nearest neighbor (5′-GA sites), l...

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Detalles Bibliográficos
Autores principales: Doherty, Erin E, Karki, Agya, Wilcox, Xander E, Mendoza, Herra G, Manjunath, Aashrita, Matos, Victorio Jauregui, Fisher, Andrew J, Beal, Peter A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638939/
https://www.ncbi.nlm.nih.gov/pubmed/36243986
http://dx.doi.org/10.1093/nar/gkac897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638939/
https://www.ncbi.nlm.nih.gov/pubmed/36243986
http://dx.doi.org/10.1093/nar/gkac897

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