Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids

[Image: see text] A convenient and simple three-component synthesis of substituted pyridylacetic acid derivatives is reported. The approach centers on the dual reactivity of Meldrum’s acid derivatives, initially as nucleophiles to perform substitution on activated pyridine-N-oxides, then as electrop...

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Autores principales: Johnson, Tarn C., Marsden, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638998/
https://www.ncbi.nlm.nih.gov/pubmed/36257810
http://dx.doi.org/10.1021/acs.joc.2c01597
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author Johnson, Tarn C.
Marsden, Stephen P.
author_facet Johnson, Tarn C.
Marsden, Stephen P.
author_sort Johnson, Tarn C.
collection PubMed
description [Image: see text] A convenient and simple three-component synthesis of substituted pyridylacetic acid derivatives is reported. The approach centers on the dual reactivity of Meldrum’s acid derivatives, initially as nucleophiles to perform substitution on activated pyridine-N-oxides, then as electrophiles with a range of nucleophiles to trigger ring-opening and decarboxylation.
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spelling pubmed-96389982022-11-08 Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids Johnson, Tarn C. Marsden, Stephen P. J Org Chem [Image: see text] A convenient and simple three-component synthesis of substituted pyridylacetic acid derivatives is reported. The approach centers on the dual reactivity of Meldrum’s acid derivatives, initially as nucleophiles to perform substitution on activated pyridine-N-oxides, then as electrophiles with a range of nucleophiles to trigger ring-opening and decarboxylation. American Chemical Society 2022-10-18 2022-11-04 /pmc/articles/PMC9638998/ /pubmed/36257810 http://dx.doi.org/10.1021/acs.joc.2c01597 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Johnson, Tarn C.
Marsden, Stephen P.
Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids
title Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids
title_full Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids
title_fullStr Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids
title_full_unstemmed Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids
title_short Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids
title_sort three-component synthesis of pyridylacetic acid derivatives by arylation/decarboxylative substitution of meldrum’s acids
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638998/
https://www.ncbi.nlm.nih.gov/pubmed/36257810
http://dx.doi.org/10.1021/acs.joc.2c01597
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