Access to Isoquinolin-2(1H)-yl-acetamides and Isoindolin-2-yl-acetamides from a Common MCR Precursor

[Image: see text] We achieved a divergent synthesis of isoquinolin-2(1H)-yl-acetamides (16 examples, up to 90% yields) and regioselective isoindolin-2-yl-acetamides (14 examples, up to 93% yields) in moderate to good yields by reacting various substituted ethanones or terminal alkynes with Ugi-4CR i...

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Detalles Bibliográficos
Autores principales: Li, Xin, Wang, Qian, Zheng, Qiang, Kurpiewska, Katarzyna, Kalinowska-Tluscik, Justyna, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639002/
https://www.ncbi.nlm.nih.gov/pubmed/36282152
http://dx.doi.org/10.1021/acs.joc.2c01905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639002/
https://www.ncbi.nlm.nih.gov/pubmed/36282152
http://dx.doi.org/10.1021/acs.joc.2c01905

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