Identification of the effect of N-glycan modification and its sialylation on proteolytic stability and glucose-stabilizing activity of glucagon-like peptide 1 by site-directed enzymatic glycosylation

In this study, an approach to prepare long-acting glucagon-like peptide 1 (GLP-1) by site-directed enzymatic glycosylation with homogeneous biantennary complex-type N-glycan has been developed. All the N-glycan-modified GLP-1 analogues preserved an unchanged secondary structure. The glycosylated GLP...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Huan, Liang, Zengwei, Wang, Yu, Li, Yingze, Wang, Ya, Guo, Xin, Guan, Wanyi, Zou, Wei, Wu, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639207/
https://www.ncbi.nlm.nih.gov/pubmed/36380917
http://dx.doi.org/10.1039/d2ra05872c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639207/
https://www.ncbi.nlm.nih.gov/pubmed/36380917
http://dx.doi.org/10.1039/d2ra05872c

Ejemplares similares