Gene prioritization based on random walks with restarts and absorbing states, to define gene sets regulating drug pharmacodynamics from single-cell analyses

Prioritizing genes for their role in drug sensitivity, is an important step in understanding drugs mechanisms of action and discovering new molecular targets for co-treatment. To formalize this problem, we consider two sets of genes X and P respectively composing the gene signature of cell sensitivi...

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Detalles Bibliográficos
Autores principales: Sales de Queiroz, Augusto, Sales Santa Cruz, Guilherme, Jean-Marie, Alain, Mazauric, Dorian, Roux, Jérémie, Cazals, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639845/
https://www.ncbi.nlm.nih.gov/pubmed/36342924
http://dx.doi.org/10.1371/journal.pone.0268956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639845/
https://www.ncbi.nlm.nih.gov/pubmed/36342924
http://dx.doi.org/10.1371/journal.pone.0268956

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