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Sequences and proteins that influence mRNA processing in Trypanosoma brucei: Evolutionary conservation of SR-domain and PTB protein functions

BACKGROUND: Spliced leader trans splicing is the addition of a short, capped sequence to the 5’ end of mRNAs. It is widespread in eukaryotic evolution, but factors that influence trans splicing acceptor site choice have been little investigated. In Kinetoplastids, all protein-coding mRNAs are 5’ tra...

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Detalles Bibliográficos
Autores principales: Waithaka, Albina, Maiakovska, Olena, Grimm, Dirk, do Nascimento, Larissa Melo, Clayton, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639853/
https://www.ncbi.nlm.nih.gov/pubmed/36288402
http://dx.doi.org/10.1371/journal.pntd.0010876