Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity

Pathological obesity and its complications are associated with an increased propensity for bone fractures. Humans with certain genetic polymorphisms at the kinase suppressor of ras2 (KSR2) locus develop severe early-onset obesity and type 2 diabetes. Both conditions are phenocopied in mice with Ksr2...

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Detalles Bibliográficos
Autores principales: Gomez, Gustavo A, Rundle, Charles H, Xing, Weirong, Kesavan, Chandrasekhar, Pourteymoor, Sheila, Lewis, Robert E, Powell, David R, Mohan, Subburaman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640193/
https://www.ncbi.nlm.nih.gov/pubmed/36342465
http://dx.doi.org/10.7554/eLife.82810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640193/
https://www.ncbi.nlm.nih.gov/pubmed/36342465
http://dx.doi.org/10.7554/eLife.82810

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