Lipid nanoparticle-mediated CRISPR/Cas9 gene editing and metabolic engineering for anticancer immunotherapy

Metabolic engineering of the tumor microenvironment has emerged as a new strategy. Lactate dehydrogenase A (LDHA) is a prominent target for metabolic engineering. Here, we designed a cationic lipid nanoparticle formulation for LDHA gene editing. The plasmid DNA delivery efficiency of our lipid nanop...

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Detalles Bibliográficos
Autores principales: Ju, Hyemin, Kim, Dongyoon, Oh, Yu-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2022
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640370/
https://www.ncbi.nlm.nih.gov/pubmed/36382304
http://dx.doi.org/10.1016/j.ajps.2022.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640370/
https://www.ncbi.nlm.nih.gov/pubmed/36382304
http://dx.doi.org/10.1016/j.ajps.2022.07.005

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