A bioinformatics approach to the identification of novel deleterious mutations of human TPMT through validated screening and molecular dynamics

Polymorphisms of Thiopurine S-methyltransferase (TPMT) are known to be associated with leukemia, inflammatory bowel diseases, and more. The objective of the present study was to identify novel deleterious missense SNPs of TPMT through a comprehensive in silico protocol. The initial SNP screening pro...

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Detalles Bibliográficos
Autores principales: Saxena, Sidharth, Krishna Murthy, T. P., Chandrashekhar, C. R., Patil, Lavan S., Aditya, Abhinav, Shukla, Rohit, Yadav, Arvind Kumar, Singh, Tiratha Raj, Samantaray, Mahesh, Ramaswamy, Amutha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640560/
https://www.ncbi.nlm.nih.gov/pubmed/36344599
http://dx.doi.org/10.1038/s41598-022-23488-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640560/
https://www.ncbi.nlm.nih.gov/pubmed/36344599
http://dx.doi.org/10.1038/s41598-022-23488-z

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