An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes

β-lactamases inactivate β-lactam antibiotics leading to drug resistance. Consequently, inhibitors of β-lactamases can combat this resistance, and the β-lactamase inhibitory protein (BLIP) is a naturally occurring inhibitor. The widespread CTX-M-14 and CTX-M-15 β-lactamases have an 83% sequence ident...

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Detalles Bibliográficos
Autores principales: Lu, Shuo, Hu, Liya, Lin, Hanfeng, Judge, Allison, Rivera, Paola, Palaniappan, Murugesan, Sankaran, Banumathi, Wang, Jin, Prasad, B. V. Venkataram, Palzkill, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640584/
https://www.ncbi.nlm.nih.gov/pubmed/36344533
http://dx.doi.org/10.1038/s41467-022-34564-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640584/
https://www.ncbi.nlm.nih.gov/pubmed/36344533
http://dx.doi.org/10.1038/s41467-022-34564-3

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