SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks

Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) has a dNTPase-independent function in promoting DNA end resection to facilitate DNA double-strand break (DSB) repair by homologous recombination (HR); however, it is not known if upstream signaling events govern this activity. Here, we...

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Detalles Bibliográficos
Autores principales: Kapoor-Vazirani, Priya, Rath, Sandip K., Liu, Xu, Shu, Zhen, Bowen, Nicole E., Chen, Yitong, Haji-Seyed-Javadi, Ramona, Daddacha, Waaqo, Minten, Elizabeth V., Danelia, Diana, Farchi, Daniela, Duong, Duc M., Seyfried, Nicholas T., Deng, Xingming, Ortlund, Eric A., Kim, Baek, Yu, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640623/
https://www.ncbi.nlm.nih.gov/pubmed/36344525
http://dx.doi.org/10.1038/s41467-022-34578-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640623/
https://www.ncbi.nlm.nih.gov/pubmed/36344525
http://dx.doi.org/10.1038/s41467-022-34578-x

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