Translocation pause of remdesivir-containing primer/template RNA duplex within SARS-CoV-2’s RNA polymerase complexes

The mechanism of remdesivir incorporation into the RNA primer by the RNA-dependent RNA polymerase (RdRp) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains to be fully established at the molecular level. Here, we compare molecular dynamics (MD) simulations after incorporation of...

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Detalles Bibliográficos
Autores principales: Shi, Yuanjun, Wang, Jimin, Batista, Victor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640752/
https://www.ncbi.nlm.nih.gov/pubmed/36387272
http://dx.doi.org/10.3389/fmolb.2022.999291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640752/
https://www.ncbi.nlm.nih.gov/pubmed/36387272
http://dx.doi.org/10.3389/fmolb.2022.999291

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