Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders. To date, a few studies have evaluated the structure-activity relationship (SAR) for CB1R positive allosteric modulators (PAMs). In this study, we separa...

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Detalles Bibliográficos
Autores principales: Brandt, Asher L., Garai, Sumanta, Zagzoog, Ayat, Hurst, Dow P., Stevenson, Lesley A., Pertwee, Roger G., Imler, Gregory H., Reggio, Patricia H., Thakur, Ganesh A., Laprairie, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640980/
https://www.ncbi.nlm.nih.gov/pubmed/36386195
http://dx.doi.org/10.3389/fphar.2022.919605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640980/
https://www.ncbi.nlm.nih.gov/pubmed/36386195
http://dx.doi.org/10.3389/fphar.2022.919605

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