Cargando…

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders. To date, a few studies have evaluated the structure-activity relationship (SAR) for CB1R positive allosteric modulators (PAMs). In this study, we separa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brandt, Asher L., Garai, Sumanta, Zagzoog, Ayat, Hurst, Dow P., Stevenson, Lesley A., Pertwee, Roger G., Imler, Gregory H., Reggio, Patricia H., Thakur, Ganesh A., Laprairie, Robert B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640980/ https://www.ncbi.nlm.nih.gov/pubmed/36386195 http://dx.doi.org/10.3389/fphar.2022.919605

Ejemplares similares

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
por: McElroy, Dan L., et al.
Publicado: (2022)

Cannabinoid receptor 1 positive allosteric modulator (GAT229) attenuates cisplatin-induced neuropathic pain in mice
por: Bagher, Amina M., et al.
Publicado: (2023)

Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia
por: Jin, Xiao-Tao, et al.
Publicado: (2011)

Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling
por: Laprairie, Robert B., et al.
Publicado: (2019)

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
por: Mizrachi, Tehila, et al.
Publicado: (2021)

Evolutionary History of the GABA Transporter (GAT) Group Revealed by Marine Invertebrate GAT-1
por: Kinjo, Azusa, et al.
Publicado: (2013)

Zwart Gat-wetenschappers bedreigd
Publicado: (2008)

Plasma membrane transporters GAT-1 and GAT-3 contribute to heterogeneity of GABAergic synapses in neocortex
por: Melone, Marcello, et al.
Publicado: (2014)

Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomolecules
por: Zagzoog, Ayat, et al.
Publicado: (2022)

Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus
por: Ghirardini, Elsa, et al.
Publicado: (2018)

A Reappraisal of GAT-1 Localization in Neocortex
por: Fattorini, Giorgia, et al.
Publicado: (2020)

Molecular Property Prediction by Combining LSTM and GAT
por: Xu, Lei, et al.
Publicado: (2023)

Forward Genetics Reveals a gatC-gatA Fusion Polypeptide Causes Mistranslation and Rifampicin Tolerance in Mycobacterium smegmatis
por: Cai, Rong-Jun, et al.
Publicado: (2020)

A Role for GAT-1 in Presynaptic GABA Homeostasis?
por: Conti, Fiorenzo, et al.
Publicado: (2011)

Toch nog een zwart gat bij CERN
Publicado: (2008)

Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor
por: Zagzoog, Ayat, et al.
Publicado: (2021)

Activity-dependent regulation of astrocyte GAT levels during synaptogenesis
por: Muthukumar, Allie K., et al.
Publicado: (2014)

GAT: a simulation framework for testing the association of genomic intervals
por: Heger, Andreas, et al.
Publicado: (2013)

Structure of the GAT domain of the endosomal adapter protein Tom1
por: Xiao, Shuyan, et al.
Publicado: (2016)

TemporalGAT: Attention-Based Dynamic Graph Representation Learning
por: Fathy, Ahmed, et al.
Publicado: (2020)

omicsGAT: Graph Attention Network for Cancer Subtype Analyses
por: Baul, Sudipto, et al.
Publicado: (2022)

EXPLORING THE ROLE OF GAT1 AND GABA IN TEMOZOLOMIDE TREATED GLIOMA
por: Poole, Alisha, et al.
Publicado: (2023)

Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor
por: Pu, Lu, et al.
Publicado: (2012)

Relationships between GAT1 and PTSD, Depression, and Substance Use Disorder
por: Bountress, Kaitlin E., et al.
Publicado: (2017)

Analysis of Different Binding Modes for Tiagabine within the GAT-1 Transporter
por: Łątka, Kamil, et al.
Publicado: (2022)

GATS tag system is compatible with biotin labelling methods for protein analysis
por: Yamada, Kohdai, et al.
Publicado: (2023)

High-Throughput Screening of Promising Redox-Active Molecules with MolGAT
por: Chaka, Mesfin Diro, et al.
Publicado: (2023)

Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint Stress
por: Kim, Hye Ji J., et al.
Publicado: (2023)

Perinatal hypoxia: different effects of the inhibitors of GABA transporters GAT1 and GAT3 on the initial velocity of [(3)H]GABA uptake by cortical, hippocampal, and thalamic nerve terminals
por: Pozdnyakova, Natalia, et al.
Publicado: (2014)

The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages
por: Gauthier, Alex G., et al.
Publicado: (2021)

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)
por: Kulkarni, Pushkar M., et al.
Publicado: (2015)

Sexual Differentiation Is Coordinately Regulated by Cryptococcus neoformans CRK1 and GAT1
por: Liu, Kuang-Hung, et al.
Publicado: (2020)

Molecular Dynamic Simulations to Probe Stereoselectivity of Tiagabine Binding with Human GAT1
por: Zafar, Sadia, et al.
Publicado: (2020)

Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity
por: Li, Yang-Yang, et al.
Publicado: (2021)

A Rolling Bearing Fault Diagnosis Method Based on the WOA-VMD and the GAT
por: Wang, Yaping, et al.
Publicado: (2023)

Impact of the mouse estrus cycle on cannabinoid receptor agonist‐induced molecular and behavioral outcomes
por: Kim, Hye Ji J., et al.
Publicado: (2022)

Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB(2)R)
por: Ferrisi, Rebecca, et al.
Publicado: (2022)

Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats
por: Brems, Brittany M., et al.
Publicado: (2023)

MatGAT: An application that generates similarity/identity matrices using protein or DNA sequences
por: Campanella, James J, et al.
Publicado: (2003)

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
por: Morlot, Cécile, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_31nktmsprj7qsji7hr3b3kspdr