Cargando…

Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway

Aberrant activation of the Wnt/β-catenin signaling pathway is implicated in most malignant cancers, especially in the initiation and progression of colorectal cancer (CRC). DKK4 is a classical inhibitory molecule of the Wnt/β-catenin pathway, but its role in CRC is ambiguous, and the molecular mecha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Junrong, Sun, Lina, Li, Yujun, Liu, Wanning, Li, Danxiu, Chen, Ping, Wang, Xin, Hui, Juan, Zhou, Jinchi, Liu, Hao, Cao, Tianyu, Pang, Maogui, Guo, Meng, Zhao, Xiaodi, Lu, Yuanyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640985/ https://www.ncbi.nlm.nih.gov/pubmed/36181792 http://dx.doi.org/10.1016/j.jbc.2022.102545

Ejemplares similares

An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC development
por: Wang, Rui, et al.
Publicado: (2021)

Imbalance of Wnt/Dkk Negative Feedback Promotes Persistent Activation of Pancreatic Stellate Cells in Chronic Pancreatitis
por: Hu, Yanling, et al.
Publicado: (2014)

HomeoboxC6 promotes metastasis by orchestrating the DKK1/Wnt/β-catenin axis in right-sided colon cancer
por: Qi, Lina, et al.
Publicado: (2021)

Roles of Wnt3a and Dkk1 in experimental periodontitis
por: Liu, Jianqi, et al.
Publicado: (2017)

Expression of DKK1 in Endometrial Endometrioid Carcinoma and Its Correlation with Wnt/β-catenin Signalling Pathway
por: Das, Abhijit, et al.
Publicado: (2023)

In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/β-catenin signaling pathway in osteosarcoma
por: Zhang, Zhi-Cai, et al.
Publicado: (2017)

Suppression of miR-708 inhibits the Wnt/β-catenin signaling pathway by activating DKK3 in adult B-all
por: Zhang, Yingjie, et al.
Publicado: (2017)

Upregulated MicroRNA-25 Mediates the Migration of Melanoma Cells by Targeting DKK3 through the WNT/β-Catenin Pathway
por: Huo, Jia, et al.
Publicado: (2016)

MYCN is a novel oncogenic target in adult B‐ALL that activates the Wnt/β‐catenin pathway by suppressing DKK3
por: Kong, Desheng, et al.
Publicado: (2018)

Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins
por: Patel, Saleha, et al.
Publicado: (2018)

Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation
por: Li, Yonghe, et al.
Publicado: (2010)

miR-33a-5p inhibits the progression of esophageal cancer through the DKK1-mediated Wnt/β-catenin pathway
por: Song, Qingping, et al.
Publicado: (2021)

Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice
por: Liu, Quan-Wen, et al.
Publicado: (2022)

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
por: Shailesh, Harshita, et al.
Publicado: (2021)

Concurrent Hypermethylation of SFRP2 and DKK2 Activates the Wnt/β-Catenin Pathway and Is Associated with Poor Prognosis in Patients with Gastric Cancer
por: Wang, Hao, et al.
Publicado: (2017)

Protective effects of miR-29a on diabetic glomerular dysfunction by modulation of DKK1/Wnt/β-catenin signaling
por: Hsu, Yung-Chien, et al.
Publicado: (2016)

Combination of Wnt/β-Catenin Targets S100A4 and DKK1 Improves Prognosis of Human Colorectal Cancer
por: Dahlmann, Mathias, et al.
Publicado: (2021)

miR-214 ameliorates acute kidney injury via targeting DKK3 and activating of Wnt/β-catenin signaling pathway
por: Zhu, Xiaoguang, et al.
Publicado: (2018)

Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells
por: Wang, Xin, et al.
Publicado: (2020)

Engineering potent long-acting variants of the Wnt inhibitor DKK2
por: Sopko, Richelle, et al.
Publicado: (2017)

Targeting the Wnt/β-catenin signaling pathway in cancer
por: Zhang, Ya, et al.
Publicado: (2020)

miR-1303 promotes the proliferation, migration and invasion of prostate cancer cells through regulating the Wnt/β-catenin pathway by targeting DKK3
por: Liu, Bo, et al.
Publicado: (2019)

CircCNIH4 inhibits gastric cancer progression via regulating DKK2 and FRZB expression and Wnt/β-catenin pathway
por: Shi, Qi, et al.
Publicado: (2021)

Endometrium-derived mesenchymal stem cells suppress progression of endometrial cancer via the DKK1-Wnt/β-catenin signaling pathway
por: Xu, Yuhui, et al.
Publicado: (2023)

MiR-92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta-catenin signaling pathway
por: Li, Qifeng, et al.
Publicado: (2013)

Transcriptional Silencing of the Wnt-Antagonist DKK1 by Promoter Methylation Is Associated with Enhanced Wnt Signaling in Advanced Multiple Myeloma
por: Kocemba, Kinga A., et al.
Publicado: (2012)

Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β-catenin and Wnt/PCP signaling pathways
por: Wang, Chengze, et al.
Publicado: (2017)

LncRNA TUG1 alleviates cardiac hypertrophy by targeting miR‐34a/DKK1/Wnt‐β‐catenin signalling
por: Fang, Qingxia, et al.
Publicado: (2020)

Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity
por: Ali, Hira, et al.
Publicado: (2019)

Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner
por: Devotta, Arun, et al.
Publicado: (2018)

Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/Β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1)
por: Huang, Zebin, et al.
Publicado: (2013)

Circular RNA Hsa_circ_0004018 Inhibits Wnt/β-Catenin Signaling Pathway by Targeting microRNA-626/DKK3 in Hepatocellular Carcinoma
por: Zhu, Pengfei, et al.
Publicado: (2020)

Wnt/β-Catenin Signaling and Obesity
por: Chen, Na, et al.
Publicado: (2018)

Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling
por: Janda, Claudia Y., et al.
Publicado: (2017)

LINC01189-miR-586-ZEB1 feedback loop regulates breast cancer progression through Wnt/β-catenin signaling pathway
por: Zhang, Di, et al.
Publicado: (2021)

Correction: Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1)
por: Huang, Zebin, et al.
Publicado: (2013)

Nomogram Incorporating the WNT/β-Catenin Signaling Pathway for Predicting the Survival of Cutaneous Melanoma
por: Zhou, Yu-Xin, et al.
Publicado: (2021)

NK4 Regulates Laryngeal Squamous Cell Carcinoma Cell Properties and Inhibits Tumorigenicity by Modulating the DKK1/Wnt/β-Catenin Axis
por: Zhang, Shoukai, et al.
Publicado: (2021)

miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/β-Catenin Pathway in Tongue Squamous Cell Carcinoma
por: Weng, Junquan, et al.
Publicado: (2017)

Phytoestrogenic molecule desmethylicaritin suppressed adipogenesis via Wnt/β-catenin signaling pathway
por: Wang, Xin-Luan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_usb2jfq5ebebvtfan4b4r4dhjh