Modular Synthesis of α,α-Diaryl α-Amino Esters via Bi(V)-Mediated Arylation/S(N)2-Displacement of Kukhtin–Ramirez Intermediates

[Image: see text] We report a concise and modular approach to α,α-diaryl α-amino esters from readily available α-keto esters. This mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate preceding sequential electrophilic arylation by Bi(V) and S...

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Detalles Bibliográficos
Autores principales: Calcatelli, Alessio, Denton, Ross M., Ball, Liam T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641671/
https://www.ncbi.nlm.nih.gov/pubmed/36278869
http://dx.doi.org/10.1021/acs.orglett.2c03201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641671/
https://www.ncbi.nlm.nih.gov/pubmed/36278869
http://dx.doi.org/10.1021/acs.orglett.2c03201

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