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Modular Synthesis of α,α-Diaryl α-Amino Esters via Bi(V)-Mediated Arylation/S(N)2-Displacement of Kukhtin–Ramirez Intermediates
[Image: see text] We report a concise and modular approach to α,α-diaryl α-amino esters from readily available α-keto esters. This mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate preceding sequential electrophilic arylation by Bi(V) and S...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641671/ https://www.ncbi.nlm.nih.gov/pubmed/36278869 http://dx.doi.org/10.1021/acs.orglett.2c03201 |