Cancer-derived extracellular succinate: a driver of cancer metastasis

Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH subunits (SDHD and SDHB) in hereditary tumors such as paraganglioma or reduction of SDHB expression in cancer results in matri...

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Detalles Bibliográficos
Autores principales: Kuo, Cheng-Chin, Wu, Jing-Yiing, Wu, Kenneth K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641777/
https://www.ncbi.nlm.nih.gov/pubmed/36344992
http://dx.doi.org/10.1186/s12929-022-00878-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641777/
https://www.ncbi.nlm.nih.gov/pubmed/36344992
http://dx.doi.org/10.1186/s12929-022-00878-z

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