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Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model

BACKGROUND: Diclofenac etalhyaluronate (DF-HA) is a recently developed analgesic conjugate of diclofenac and hyaluronic acid that has analgesic and anti-inflammatory effects on acute arthritis. In this study, we investigated its analgesic effect on osteoarthritis, using a rat model of monoiodoacetat...

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Detalles Bibliográficos
Autores principales: Arai, Takahito, Suzuki-Narita, Miyako, Takeuchi, Jun, Tajiri, Ikuko, Inage, Kazuhide, Kawarai, Yuya, Eguchi, Yawara, Shiga, Yasuhiro, Hozumi, Takashi, Kim, Geundong, Tsuchiya, Ryuto, Otagiri, Takuma, Mukaihata, Tomohito, Hishiya, Takahisa, Toshi, Noriyasu, Okuyama, Kohei, Tokeshi, Soichiro, Furuya, Takeo, Maki, Satoshi, Matsuura, Yusuke, Suzuki, Takane, Nakamura, Junichi, Hagiwara, Shigeo, Ohtori, Seiji, Orita, Sumihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641934/
https://www.ncbi.nlm.nih.gov/pubmed/36344944
http://dx.doi.org/10.1186/s12891-022-05937-y