Cargando…

General Theory of Specific Binding: Insights from a Genetic-Mechano-Chemical Protein Model

Proteins need to selectively interact with specific targets among a multitude of similar molecules in the cell. However, despite a firm physical understanding of binding interactions, we lack a general theory of how proteins evolve high specificity. Here, we present such a model that combines chemis...

Descripción completa

Detalles Bibliográficos
Autores principales:	McBride, John M, Eckmann, Jean-Pierre, Tlusty, Tsvi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641994/ https://www.ncbi.nlm.nih.gov/pubmed/36208205 http://dx.doi.org/10.1093/molbev/msac217

Ejemplares similares

Slowest-first protein translation scheme: Structural asymmetry and co-translational folding
por: McBride, John M., et al.
Publicado: (2021)

Green function of correlated genes in a minimal mechanical model of protein evolution
por: Dutta, Sandipan, et al.
Publicado: (2018)

αβDCA method identifies unspecific binding but specific disruption of the group I intron by the StpA chaperone
por: Reinharz, Vladimir, et al.
Publicado: (2020)

Leaders of Neuronal Cultures in a Quorum Percolation Model
por: Eckmann, Jean-Pierre, et al.
Publicado: (2010)

Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa)
por: Perdomo-Sabogal, Alvaro, et al.
Publicado: (2016)

A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function
por: Schroeder, Courtney M, et al.
Publicado: (2020)

Strong Purifying Selection in Haploid Tissue–Specific Genes of Scots Pine Supports the Masking Theory
por: Cervantes, Sandra, et al.
Publicado: (2023)

Deciphering the Genetic Basis of Silkworm Cocoon Colors Provides New Insights into Biological Coloration and Phenotypic Diversification
por: Lu, Yaru, et al.
Publicado: (2023)

Evolution of Prdm Genes in Animals: Insights from Comparative Genomics
por: Vervoort, Michel, et al.
Publicado: (2016)

Spontaneous chiral symmetry breaking in a random driven chemical system
por: Piñeros, William D., et al.
Publicado: (2022)

267 Spanish Exomes Reveal Population-Specific Differences in Disease-Related Genetic Variation
por: Dopazo, Joaquín, et al.
Publicado: (2016)

Reconstructing the Human Genetic History of Mainland Southeast Asia: Insights from Genome-Wide Data from Thailand and Laos
por: Kutanan, Wibhu, et al.
Publicado: (2021)

Evolutionary Insights into Premetazoan Functions of the Neuronal Protein Homer
por: Burkhardt, Pawel, et al.
Publicado: (2014)

Conformational Proofreading: The Impact of Conformational Changes on the Specificity of Molecular Recognition
por: Savir, Yonatan, et al.
Publicado: (2007)

Host Range and Genetic Plasticity Explain the Coexistence of Integrative and Extrachromosomal Mobile Genetic Elements
por: Cury, Jean, et al.
Publicado: (2018)

Were Ancestral Proteins Less Specific?
por: Wheeler, Lucas C, et al.
Publicado: (2021)

Genomic Signatures for Species-Specific Adaptation in Lake Victoria Cichlids Derived from Large-Scale Standing Genetic Variation
por: Nakamura, Haruna, et al.
Publicado: (2021)

Diverse Eukaryotic CGG-Binding Proteins Produced by Independent Domestications of hAT Transposons
por: Yellan, Isaac, et al.
Publicado: (2021)

Convergence of Domain Architecture, Structure, and Ligand Affinity in Animal and Plant RNA-Binding Proteins
por: Dias, Raquel, et al.
Publicado: (2017)

Both Maintenance and Avoidance of RNA-Binding Protein Interactions Constrain Coding Sequence Evolution
por: Savisaar, Rosina, et al.
Publicado: (2017)

Reverse Chemical Ecology Suggests Putative Primate Pheromones
por: Zaremska, Valeriia, et al.
Publicado: (2021)

Insights into RAG Evolution from the Identification of “Missing Link” Family A RAGL Transposons
por: Martin, Eliza C, et al.
Publicado: (2023)

Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes
por: Abrusán, György, et al.
Publicado: (2019)

Emergence of Novel RNA-Editing Sites by Changes in the Binding Affinity of a Conserved PPR Protein
por: Loiacono, F Vanessa, et al.
Publicado: (2022)

Contrasting Gene Decay in Subterranean Vertebrates: Insights from Cavefishes and Fossorial Mammals
por: Policarpo, Maxime, et al.
Publicado: (2020)

Comparative Population Transcriptomics Provide New Insight into the Evolutionary History and Adaptive Potential of World Ocean Krill
por: Choquet, Marvin, et al.
Publicado: (2023)

Insights from the Shell Proteome: Biomineralization to Adaptation
por: Arivalagan, Jaison, et al.
Publicado: (2017)

Phylotranscriptomic Insights into the Diversification of Endothermic Thunnus Tunas
por: Ciezarek, Adam G, et al.
Publicado: (2019)

A Population-Genetic Lens into the Process of Gene Loss Following Whole-Genome Duplication
por: Johri, Parul, et al.
Publicado: (2022)

Deuterostome Genomics: Lineage-Specific Protein Expansions That Enabled Chordate Muscle Evolution
por: Inoue, Jun, et al.
Publicado: (2018)

Are Nonsynonymous Transversions Generally More Deleterious than Nonsynonymous Transitions?
por: Zou, Zhengting, et al.
Publicado: (2020)

Evolution of miRNA-Binding Sites and Regulatory Networks in Cichlids
por: Mehta, Tarang K, et al.
Publicado: (2022)

Consequences of Asexuality in Natural Populations: Insights from Stick Insects
por: Bast, Jens, et al.
Publicado: (2018)

The Genomes of Two Billfishes Provide Insights into the Evolution of Endothermy in Teleosts
por: Wu, Baosheng, et al.
Publicado: (2021)

Site-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs
por: Doud, Michael B., et al.
Publicado: (2015)

A General Model to Explain Repeated Turnovers of Sex Determination in the Salicaceae
por: Yang, Wenlu, et al.
Publicado: (2020)

Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling
por: Nevers, Yannis, et al.
Publicado: (2017)

Insights into Platypus Population Structure and History from Whole-Genome Sequencing
por: Martin, Hilary C, et al.
Publicado: (2018)

Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in Vertebrates
por: Wang, Bei, et al.
Publicado: (2019)

Population Genomics Provide Insights into the Evolution and Adaptation of the Asia Corn Borer
por: Peng, Yan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ohlbij7mjll32v1c3kcd1tg96c