Structure and flexibility of the yeast NuA4 histone acetyltransferase complex

The NuA4 protein complex acetylates histones H4 and H2A to activate both transcription and DNA repair. We report the 3.1-Å resolution cryo-electron microscopy structure of the central hub of NuA4, which flexibly tethers the histone acetyltransferase (HAT) and Trimer Independent of NuA4 involved in T...

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Detalles Bibliográficos
Autores principales: Zukin, Stefan A, Marunde, Matthew R, Popova, Irina K, Soczek, Katarzyna M, Nogales, Eva, Patel, Avinash B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643008/
https://www.ncbi.nlm.nih.gov/pubmed/36263929
http://dx.doi.org/10.7554/eLife.81400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643008/
https://www.ncbi.nlm.nih.gov/pubmed/36263929
http://dx.doi.org/10.7554/eLife.81400

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