IgTreeZ, A Toolkit for Immunoglobulin Gene Lineage Tree-Based Analysis, Reveals CDR3s Are Crucial for Selection Analysis

Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees were used over the last four decades to model SHM and the selection mechanisms operating on B cell clones. We hereby presen...

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Detalles Bibliográficos
Autores principales: Neuman, Hadas, Arrouasse, Jessica, Kedmi, Meirav, Cerutti, Andrea, Magri, Giuliana, Mehr, Ramit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643157/
https://www.ncbi.nlm.nih.gov/pubmed/36389731
http://dx.doi.org/10.3389/fimmu.2022.822834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643157/
https://www.ncbi.nlm.nih.gov/pubmed/36389731
http://dx.doi.org/10.3389/fimmu.2022.822834

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