CRISPR/Cas9 RET Gene Knockout in Medullary Thyroid Carcinoma Cell-lines: Optimization and Validation

BACKGROUND: Medullary Thyroid Cancer (MTC) is a very aggressive type of thyroid carcinoma. Mutation in RET proto-oncogene is demonstrated in MTC development. We aimed to knock-out of RET-oncogene using CRISPR/Cas9 genome editing method in MTC cell-lines. METHODS: This research was conducted in Shahi...

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Detalles Bibliográficos
Autores principales: Zarif-Yeganeh, Marjan, Farhud, Dariush D, Rahimpour, Azam, Sheikholeslami, Sara, Shivaei, Setareh, Hedayati, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643222/
https://www.ncbi.nlm.nih.gov/pubmed/36407731
http://dx.doi.org/10.18502/ijph.v51i5.9424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643222/
https://www.ncbi.nlm.nih.gov/pubmed/36407731
http://dx.doi.org/10.18502/ijph.v51i5.9424

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