A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6

Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATP-competitive inhibitor of PGK1 w...

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Detalles Bibliográficos
Autores principales: Liao, Liping, Dang, Wenzhen, Lin, Tingting, Yu, Jinghua, Liu, Tonghai, Li, Wen, Xiao, Senhao, Feng, Lei, Huang, Jing, Fu, Rong, Li, Jiacheng, Liu, Liping, Wang, Mingchen, Tao, Hongru, Jiang, Hualiang, Chen, Kaixian, Diao, Xingxing, Zhou, Bing, Shen, Xiaoyan, Luo, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643279/
https://www.ncbi.nlm.nih.gov/pubmed/36386479
http://dx.doi.org/10.1016/j.apsb.2022.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643279/
https://www.ncbi.nlm.nih.gov/pubmed/36386479
http://dx.doi.org/10.1016/j.apsb.2022.05.012

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