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Photoredox C–H functionalization leads the site-selective phenylalanine bioconjugation

Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine residue in their sequenced, showing the potential...

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Detalles Bibliográficos
Autores principales: Weng, Yue, Su, Chun-Jen, Jiang, Haoyang, Chiang, Chien-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643349/
https://www.ncbi.nlm.nih.gov/pubmed/36348051
http://dx.doi.org/10.1038/s41598-022-23481-6