The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy

The treatment of acute leukemia is challenging because of the genetic heterogeneity between and within patients. Leukemic stem cells (LSCs) are relatively drug-resistant and frequently relapse. Their plasticity and capacity to adapt to extracellular stress, in which mitochondrial metabolism and auto...

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Detalles Bibliográficos
Autores principales: Lima, Keli, Pereira-Martins, Diego Antonio, de Miranda, Lívia Bassani Lins, Coelho-Silva, Juan Luiz, Leandro, Giovana da Silva, Weinhäuser, Isabel, Cavaglieri, Rita de Cássia, Leal, Aline de Medeiros, da Silva, Wellington Fernandes, Lange, Ana Paula Alencar de Lima, Velloso, Elvira Deolinda Rodrigues Pereira, Griessinger, Emmanuel, Hilberink, Jacobien R., Ammatuna, Emanuele, Huls, Gerwin, Schuringa, Jan Jacob, Rego, Eduardo Magalhães, Machado-Neto, João Agostinho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643393/
https://www.ncbi.nlm.nih.gov/pubmed/36347832
http://dx.doi.org/10.1038/s41408-022-00747-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643393/
https://www.ncbi.nlm.nih.gov/pubmed/36347832
http://dx.doi.org/10.1038/s41408-022-00747-w

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