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Paraspeckle subnuclear bodies depend on dynamic heterodimerisation of DBHS RNA-binding proteins via their structured domains

RNA-binding proteins of the DBHS (Drosophila Behavior Human Splicing) family, NONO, SFPQ, and PSPC1 have numerous roles in genome stability and transcriptional and posttranscriptional regulation. Critical to DBHS activity is their recruitment to distinct subnuclear locations, for example, paraspeckl...

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Detalles Bibliográficos
Autores principales: Lee, Pei Wen, Marshall, Andrew C., Knott, Gavin J., Kobelke, Simon, Martelotto, Luciano, Cho, Ellie, McMillan, Paul J., Lee, Mihwa, Bond, Charles S., Fox, Archa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643411/
https://www.ncbi.nlm.nih.gov/pubmed/36209820
http://dx.doi.org/10.1016/j.jbc.2022.102563