Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer

BACKGROUND: We report copy-number profiling by low-pass WGS (LP-WGS) in individual circulating tumour cells (CTCs) for guiding treatment in patients with metastatic breast cancer (MBC), comparing CTC results with mutations detected in circulating tumour DNA (ctDNA) in the same blood samples. METHODS...

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Detalles Bibliográficos
Autores principales: Fernandez-Garcia, Daniel, Nteliopoulos, Georgios, Hastings, Robert K., Rushton, Amelia, Page, Karen, Allsopp, Rebecca C., Ambasager, Bana, Gleason, Kelly, Guttery, David S., Ali, Simak, Charles Coombes, R., Shaw, Jacqueline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643413/
https://www.ncbi.nlm.nih.gov/pubmed/36088510
http://dx.doi.org/10.1038/s41416-022-01962-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643413/
https://www.ncbi.nlm.nih.gov/pubmed/36088510
http://dx.doi.org/10.1038/s41416-022-01962-9

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