Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells

Targeting TEAD autopalmitoylation has been proposed as a therapeutic approach for YAP-dependent cancers. Here we show that TEAD palmitoylation inhibitor MGH-CP1 and analogues block cancer cell “stemness”, organ overgrowth and tumor initiation in vitro and in vivo. MGH-CP1 sensitivity correlates sign...

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Detalles Bibliográficos
Autores principales: Sun, Yang, Hu, Lu, Tao, Zhipeng, Jarugumilli, Gopala K., Erb, Hannah, Singh, Alka, Li, Qi, Cotton, Jennifer L., Greninger, Patricia, Egan, Regina K., Tony Ip, Y., Benes, Cyril H., Che, Jianwei, Mao, Junhao, Wu, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643419/
https://www.ncbi.nlm.nih.gov/pubmed/36347861
http://dx.doi.org/10.1038/s41467-022-34559-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643419/
https://www.ncbi.nlm.nih.gov/pubmed/36347861
http://dx.doi.org/10.1038/s41467-022-34559-0

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