Oxidative stress–induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain

Calcium/calmodulin-dependent protein kinase II δ (CaMKIIδ) has a pivotal role in cardiac signaling. Constitutive and deleterious CaMKII “autonomous” activation is induced by oxidative stress, and the previously reported mechanism involves oxidation of methionine residues in the regulatory domain. He...

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Detalles Bibliográficos
Autores principales: Rocco-Machado, Nathália, Lai, Lo, Kim, Geumsoo, He, Yi, Luczak, Elizabeth D., Anderson, Mark E., Levine, Rodney L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643438/
https://www.ncbi.nlm.nih.gov/pubmed/36220393
http://dx.doi.org/10.1016/j.jbc.2022.102579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643438/
https://www.ncbi.nlm.nih.gov/pubmed/36220393
http://dx.doi.org/10.1016/j.jbc.2022.102579

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