Cell division drives DNA methylation loss in late-replicating domains in primary human cells

DNA methylation undergoes dramatic age-related changes, first described more than four decades ago. Loss of DNA methylation within partially methylated domains (PMDs), late-replicating regions of the genome attached to the nuclear lamina, advances with age in normal tissues, and is further exacerbat...

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Detalles Bibliográficos
Autores principales: Endicott, Jamie L., Nolte, Paula A., Shen, Hui, Laird, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643452/
https://www.ncbi.nlm.nih.gov/pubmed/36347867
http://dx.doi.org/10.1038/s41467-022-34268-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643452/
https://www.ncbi.nlm.nih.gov/pubmed/36347867
http://dx.doi.org/10.1038/s41467-022-34268-8

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