Matching amino acids membrane preference profile to improve activity of antimicrobial peptides

Antimicrobial peptides (AMPs) are cationic antibiotics that can kill multidrug-resistant bacteria via membrane insertion. However, their weak activity limits their clinical use. Ironically, the cationic charge of AMPs is essential for membrane binding, but it obstructs membrane insertion. In this st...

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Detalles Bibliográficos
Autores principales: Kim, Shanghyeon, Lee, Jaehoo, Lee, Sol, Kim, Hyein, Sim, Ji-Yeong, Pak, Boryeong, Kim, Kyeongmin, Il Kim, Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643456/
https://www.ncbi.nlm.nih.gov/pubmed/36347951
http://dx.doi.org/10.1038/s42003-022-04164-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643456/
https://www.ncbi.nlm.nih.gov/pubmed/36347951
http://dx.doi.org/10.1038/s42003-022-04164-4

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