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Matching amino acids membrane preference profile to improve activity of antimicrobial peptides
Antimicrobial peptides (AMPs) are cationic antibiotics that can kill multidrug-resistant bacteria via membrane insertion. However, their weak activity limits their clinical use. Ironically, the cationic charge of AMPs is essential for membrane binding, but it obstructs membrane insertion. In this st...
Autores principales: | Kim, Shanghyeon, Lee, Jaehoo, Lee, Sol, Kim, Hyein, Sim, Ji-Yeong, Pak, Boryeong, Kim, Kyeongmin, Il Kim, Jae |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643456/ https://www.ncbi.nlm.nih.gov/pubmed/36347951 http://dx.doi.org/10.1038/s42003-022-04164-4 |
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