Identification of a potent dual-function inhibitor for hIMPDH isoforms by computer-aided drug discovery approaches

Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in de novo biosynthesis of purine nucleotides. Due to this important role, it is a great target to drug discovery for a wide range of activities, especially immunosuppressant in heart and kidney transplantation. Both human IMPDH isoforms ar...

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Detalles Bibliográficos
Autores principales: Yazdani, Meysam, Zamani, Javad, Fatemi, Seyed Safa-Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643795/
https://www.ncbi.nlm.nih.gov/pubmed/36386211
http://dx.doi.org/10.3389/fphar.2022.977568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643795/
https://www.ncbi.nlm.nih.gov/pubmed/36386211
http://dx.doi.org/10.3389/fphar.2022.977568

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