Cargando…

Identification of a potent dual-function inhibitor for hIMPDH isoforms by computer-aided drug discovery approaches

Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in de novo biosynthesis of purine nucleotides. Due to this important role, it is a great target to drug discovery for a wide range of activities, especially immunosuppressant in heart and kidney transplantation. Both human IMPDH isoforms ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yazdani, Meysam, Zamani, Javad, Fatemi, Seyed Safa-Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643795/ https://www.ncbi.nlm.nih.gov/pubmed/36386211 http://dx.doi.org/10.3389/fphar.2022.977568

Ejemplares similares

Newer human inosine 5′-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents
por: Shah, Chetan P., et al.
Publicado: (2018)

Different Characteristics and Nucleotide Binding Properties of Inosine Monophosphate Dehydrogenase (IMPDH) Isoforms
por: Thomas, Elaine C., et al.
Publicado: (2012)

Discovery of New Potent anti-MERS CoV Fusion Inhibitors
por: Kandeel, Mahmoud, et al.
Publicado: (2021)

Discovery of Potent EGFR Inhibitors With 6-Arylureido-4-anilinoquinazoline Derivatives
por: Li, Meng, et al.
Publicado: (2021)

Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors
por: Zhang, Yuejuan, et al.
Publicado: (2022)

Discovery of a potent olaparib–chlorambucil hybrid inhibitor of PARP1 for the treatment of cancer
por: Qin, Hongyu, et al.
Publicado: (2023)

DeepMalaria: Artificial Intelligence Driven Discovery of Potent Antiplasmodials
por: Keshavarzi Arshadi, Arash, et al.
Publicado: (2020)

Discovery of a Potent and Orally Active Dual GPBAR1/CysLT(1)R Modulator for the Treatment of Metabolic Fatty Liver Disease
por: Fiorucci, Stefano, et al.
Publicado: (2022)

Discovery and Identification of Pyrazolopyramidine Analogs as Novel Potent Androgen Receptor Antagonists
por: Wang, Lingyan, et al.
Publicado: (2018)

Cytoophidium assembly reflects upregulation of IMPDH activity
por: Chang, Chia-Chun, et al.
Publicado: (2015)

Interfilament interaction between IMPDH and CTPS cytoophidia
por: Chang, Chia‐Chun, et al.
Publicado: (2018)

IMPDH dysregulation in disease: a mini review
por: Burrell, Anika L., et al.
Publicado: (2022)

Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index
por: Hori, Kiminori, et al.
Publicado: (2018)

Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2
por: Song, Yun-Qing, et al.
Publicado: (2021)

Discovery of potent and noncovalent KRAS(G12D) inhibitors: Structure-based virtual screening and biological evaluation
por: Wang, Yuting, et al.
Publicado: (2022)

Depinar, a drug that potentially inhibits the binding and entry of COVID-19 into host cells based on computer-aided studies
por: Yazdani, Meysam, et al.
Publicado: (2021)

Discovery of a Novel Na(v)1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy
por: Zhang, Yunxiao, et al.
Publicado: (2018)

Discovery of N-(2-Aminophenyl)-4-(bis(2-chloroethyl)amino)Benzamide as a Potent Histone Deacetylase Inhibitor
por: Zhang, Lihui, et al.
Publicado: (2019)

A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells
por: Cleghorn, Whitney M., et al.
Publicado: (2021)

Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
por: Giovannuzzi, Simone, et al.
Publicado: (2023)

AIDE: annotation-assisted isoform discovery with high precision
por: Li, Wei Vivian, et al.
Publicado: (2019)

Introduction to the BioChemical Library (BCL): An Application-Based Open-Source Toolkit for Integrated Cheminformatics and Machine Learning in Computer-Aided Drug Discovery
por: Brown, Benjamin P., et al.
Publicado: (2022)

Identification of selective inhibitors of Helicobacter pylori IMPDH as a targeted therapy for the infection
por: Juvale, Kapil, et al.
Publicado: (2019)

Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening
por: Sarwono, Albertus Eka Yudistira, et al.
Publicado: (2018)

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds
por: Makowska-Grzyska, Magdalena, et al.
Publicado: (2015)

IMP/GTP balance modulates cytoophidium assembly and IMPDH activity
por: Keppeke, Gerson Dierley, et al.
Publicado: (2018)

Licraside as novel potent FXR agonist for relieving cholestasis: structure-based drug discovery and biological evaluation studies
por: Xi, Lili, et al.
Publicado: (2023)

In Silico Design of Human IMPDH Inhibitors Using Pharmacophore Mapping and Molecular Docking Approaches
por: Li, Rui-Juan, et al.
Publicado: (2015)

Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents
por: Yang, Chao, et al.
Publicado: (2022)

Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice
por: Zhang, Rongjie, et al.
Publicado: (2022)

Expression of IMPDH mRNA after Mycophenolate Administration in Male Volunteers
por: Kim, Sollip, et al.
Publicado: (2014)

Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties
por: Alexandre, Thomas, et al.
Publicado: (2015)

Reconstituted IMPDH polymers accommodate both catalytically active and inactive conformations
por: Anthony, Sajitha A., et al.
Publicado: (2017)

Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells
por: Ni, Shiwen, et al.
Publicado: (2021)

Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1
por: Zhang, Jing, et al.
Publicado: (2022)

Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1
por: Pang, Hui-Lin, et al.
Publicado: (2022)

Developmental Genes and Regulatory Proteins, Domains of Cognitive Impairment in Schizophrenia Spectrum Psychosis and Implications for Antipsychotic Drug Discovery: The Example of Dysbindin-1 Isoforms and Beyond
por: Waddington, John L., et al.
Publicado: (2020)

Current Evidence on Computer-Aided Diagnosis of Celiac Disease: Systematic Review
por: Molder, Adriana, et al.
Publicado: (2020)

Computer-aided drug discovery
por: Bajorath, Jürgen
Publicado: (2015)

Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport
por: Kahnt, Astrid S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cugjcj7ko4s1v8abe728bcdgpg