Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy

Emerging evidence from Alzheimer’s disease (AD) patients suggests that reducing tau pathology can restore cognitive and memory loss. To reduce tau pathology, it is critical to find brain-permeable tau-degrading small molecules that are safe and effective. HDAC6 inhibition has long been considered a...

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Detalles Bibliográficos
Autores principales: Sreenivasmurthy, Sravan Gopalkrishnashetty, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Reddi, Rambabu N., Kammala, Ananth Kumar, Vasudevan, Karthick, Senapati, Sanjib, Zhu, Zhou, Su, Cheng-Fu, Liu, Jia, Guan, Xin-Jie, Chua, Ka-Kit, Cheung, King-Ho, Chen, Hubiao, Zhang, Hong-Jie, Zhang, Yuan, Song, Ju-Xian, Kumar Durairajan, Siva Sundara, Li, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643865/
https://www.ncbi.nlm.nih.gov/pubmed/36387280
http://dx.doi.org/10.3389/fmolb.2022.1030534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643865/
https://www.ncbi.nlm.nih.gov/pubmed/36387280
http://dx.doi.org/10.3389/fmolb.2022.1030534

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