CD3e-immunotoxin spares CD62L(lo) Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3e(hi) T cells

CD3-epsilon(CD3e) immunotoxins (IT), a promising precision reagent for various clinical conditions requiring effective depletion of T cells, often shows limited treatment efficacy for largely unknown reasons. Tissue-resident T cells that persist in peripheral tissues have been shown to play pivotal...

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Detalles Bibliográficos
Autores principales: Kim, Shihyoung, Shukla, Rajni Kant, Yu, Hannah, Baek, Alice, Cressman, Sophie G., Golconda, Sarah, Lee, Ga-Eun, Choi, Hyewon, Reneau, John C., Wang, Zhirui, Huang, Christene A., Liyanage, Namal P. M., Kim, Sanggu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643874/
https://www.ncbi.nlm.nih.gov/pubmed/36389741
http://dx.doi.org/10.3389/fimmu.2022.1011190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643874/
https://www.ncbi.nlm.nih.gov/pubmed/36389741
http://dx.doi.org/10.3389/fimmu.2022.1011190

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