Age-induced prostaglandin E(2) impairs mitochondrial fitness and increases mortality to influenza infection

Aging impairs the immune responses to influenza A virus (IAV), resulting in increased mortality to IAV infections in older adults. However, the factors within the aged lung that compromise host defense to IAV remain unknown. Using a murine model and human samples, we identified prostaglandin E(2) (P...

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Detalles Bibliográficos
Autores principales: Chen, Judy, Deng, Jane C., Zemans, Rachel L., Bahmed, Karim, Kosmider, Beata, Zhang, Min, Peters-Golden, Marc, Goldstein, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643978/
https://www.ncbi.nlm.nih.gov/pubmed/36351902
http://dx.doi.org/10.1038/s41467-022-34593-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643978/
https://www.ncbi.nlm.nih.gov/pubmed/36351902
http://dx.doi.org/10.1038/s41467-022-34593-y

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