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Age-induced prostaglandin E(2) impairs mitochondrial fitness and increases mortality to influenza infection
Aging impairs the immune responses to influenza A virus (IAV), resulting in increased mortality to IAV infections in older adults. However, the factors within the aged lung that compromise host defense to IAV remain unknown. Using a murine model and human samples, we identified prostaglandin E(2) (P...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643978/ https://www.ncbi.nlm.nih.gov/pubmed/36351902 http://dx.doi.org/10.1038/s41467-022-34593-y |