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Elongator promotes neuritogenesis via regulation of tau stability through acly activity

The six subunits (Elp1 to Elp6) Elongator complex promotes specific uridine modifications in tRNA’s wobble site. Moreover, this complex has been indirectly involved in the regulation of α-tubulin acetylation in microtubules (MTs) via the stabilization of ATP-Citrate Lyase (Acly), the main cytosolic...

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Detalles Bibliográficos
Autores principales: Shilian, Michal, Even, Aviel, Gast, Hila, Nguyen, Laurent, Weil, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644021/
https://www.ncbi.nlm.nih.gov/pubmed/36393857
http://dx.doi.org/10.3389/fcell.2022.1015125