Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR

Summary: There is strong evidence that physical activity has a profound protective effect against multiple types of cancer. Here, we show that this effect may be mediated by factors released from skeletal muscle during simulated exercise, in situ, which suppress canonical anabolic signaling in breas...

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Autores principales: Davis, Amanda R., Goodenough, Chelsea G., Westerlind, Kim C., Strange, Robert, Deaver, John W., Ryan, Patrick J., Riechman, Steven E., Fluckey, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644210/
https://www.ncbi.nlm.nih.gov/pubmed/36388131
http://dx.doi.org/10.3389/fphys.2022.1033585
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author Davis, Amanda R.
Goodenough, Chelsea G.
Westerlind, Kim C.
Strange, Robert
Deaver, John W.
Ryan, Patrick J.
Riechman, Steven E.
Fluckey, James D.
author_facet Davis, Amanda R.
Goodenough, Chelsea G.
Westerlind, Kim C.
Strange, Robert
Deaver, John W.
Ryan, Patrick J.
Riechman, Steven E.
Fluckey, James D.
author_sort Davis, Amanda R.
collection PubMed
description Summary: There is strong evidence that physical activity has a profound protective effect against multiple types of cancer. Here, we show that this effect may be mediated by factors released from skeletal muscle during simulated exercise, in situ, which suppress canonical anabolic signaling in breast cancer. We report attenuated growth of MCF7 breast cancer cells in the presence of a rodent-derived exercise conditioned perfusate, independent of prior exercise training. This reduction was concomitant with increased levels of DEPTOR protein and reduced mTOR activity.
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spelling pubmed-96442102022-11-15 Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR Davis, Amanda R. Goodenough, Chelsea G. Westerlind, Kim C. Strange, Robert Deaver, John W. Ryan, Patrick J. Riechman, Steven E. Fluckey, James D. Front Physiol Physiology Summary: There is strong evidence that physical activity has a profound protective effect against multiple types of cancer. Here, we show that this effect may be mediated by factors released from skeletal muscle during simulated exercise, in situ, which suppress canonical anabolic signaling in breast cancer. We report attenuated growth of MCF7 breast cancer cells in the presence of a rodent-derived exercise conditioned perfusate, independent of prior exercise training. This reduction was concomitant with increased levels of DEPTOR protein and reduced mTOR activity. Frontiers Media S.A. 2022-10-21 /pmc/articles/PMC9644210/ /pubmed/36388131 http://dx.doi.org/10.3389/fphys.2022.1033585 Text en Copyright © 2022 Davis, Goodenough, Westerlind, Strange, Deaver, Ryan, Riechman and Fluckey. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Davis, Amanda R.
Goodenough, Chelsea G.
Westerlind, Kim C.
Strange, Robert
Deaver, John W.
Ryan, Patrick J.
Riechman, Steven E.
Fluckey, James D.
Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR
title Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR
title_full Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR
title_fullStr Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR
title_full_unstemmed Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR
title_short Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR
title_sort myokines derived from contracting skeletal muscle suppress anabolism in mcf7 breast cancer cells by inhibiting mtor
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644210/
https://www.ncbi.nlm.nih.gov/pubmed/36388131
http://dx.doi.org/10.3389/fphys.2022.1033585
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