Regioselective α-addition of vinylogous α-ketoester enolate in organocatalytic asymmetric Michael reactions: enantioselective synthesis of Rauhut–Currier type products

Catalytic asymmetric α-regioselective Michael additions of vinylogous α-ketoester enolate are described herein. With 0.1–1.0 mol% loadings of a chiral bifunctional organocatalyst, the addition of a deconjugated α-keto ester to a series of nitroolefins, including the challenging β-alkylnitroalkenes,...

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Detalles Bibliográficos
Autores principales: Weng, Zhibing, Zhou, Ying, Yue, Xin, Jiang, Feng, Guo, Wengang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644254/
https://www.ncbi.nlm.nih.gov/pubmed/36415556
http://dx.doi.org/10.1039/d2ra06416b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644254/
https://www.ncbi.nlm.nih.gov/pubmed/36415556
http://dx.doi.org/10.1039/d2ra06416b

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