Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis using UK Biobank data: population based cohort study

OBJECTIVE: To evaluate the benefit of combining polygenic risk scores with the QCancer-10 (colorectal cancer) prediction model for non-genetic risk to identify people at highest risk of colorectal cancer. DESIGN: Population based cohort study. SETTING: Data from the UK Biobank study, collected betwe...

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Detalles Bibliográficos
Autores principales: Briggs, Sarah E W, Law, Philip, East, James E, Wordsworth, Sarah, Dunlop, Malcolm, Houlston, Richard, Hippisley-Cox, Julia, Tomlinson, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644277/
https://www.ncbi.nlm.nih.gov/pubmed/36351667
http://dx.doi.org/10.1136/bmj-2022-071707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644277/
https://www.ncbi.nlm.nih.gov/pubmed/36351667
http://dx.doi.org/10.1136/bmj-2022-071707

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